ENPEP and neoplasm: Figure 1A shows no significant differences in the total number of non-silent, protein-coding mutations between GEJAC and tEAC tumor groups, while Figure 1B shows that GEJAC mutations are significantly (p=0.02 Wilcoxon Rank-sum test) less likely to involve the ApA dinucleotide, a signature mutation associated with EAC [22, 23].