BSG and hepatocellular carcinoma: Following CD147 knockdown, Caspase-3 is activated in HCC cells [10]; further, increased Caspase-3 and PARP cleavages occur in human leukemic monocyte lymphoma U937 cells [37], whereas the addition of CD147 to melanoma cell lines has been shown to result in a decrease in Caspase-3/7 activity [38].