ERRγ's role in breast cancer is complex and context-dependent; while several studies show an association between this receptor and indicators of good prognosis [37] or directly demonstrate a growth-suppressive role [40, 41], others report that it can promote estrogen-independent and Tamoxifen-resistant growth [42–46], and metabolically reprogram non-transformed mammary epithelial cells to successfully adapt to anoikis [47]. The gene discussed is ESRRG; the disease is breast cancer.