In prostate cancer, reduced expression of E-cadherin leads to docetaxel insensitivity, which is partially mediated by reduced miR-205 expression.49 miR-205 also enhances cisplatin toxicity in castration-resistant prostate cancer cells by targeting RAB27A and LAMP3,50 whereas in lung cancer, miR-205 overexpression is associated with carboplatin insensitivity by altering the expression of apoptosis-related genes.51 However, the effect of miR-205 in breast cancer chemoresistance is still poorly understood. The gene discussed is RAB27A; the disease is Familial prostate cancer.