AKT1 and cancer: The PI3K/AKT signaling pathway is frequently dysregulated in human cancer and has been implicated in chemoresistance.30, 31 We also observed that the induction of cell apoptosis by miR-205 overexpression in both drug-resistant cells was associated with a significant reduction in AKT phosphorylation, suggesting a decrease in PI3K activity (Figure 2h).