These findings suggest that induction of RIPK1 and RIPK3 by TNF in TECs is independent of NFκB and that constitutive overexpression of c-FLIP in the tumor cells35, 36 may confer resistance against caspase 8-induced apoptosis in RCC resulting in dominance of necroptotic cell death. This evidence concerns the gene NFKB1 and neoplasm.