ATG7 and acute promyelocytic leukemia: Furthermore, we knocked down autophagy-related gene Atg7 using small interfering RNA (siRNA) to confirm the role of autophagy in ETosis in APL.35 As shown in Figure 7a, inhibition of autophagy nearly abolished APL serum-induced autophagy as the markedly decreased conversion of LC3B-I to LC3B-II.