SLC2A1 and neoplasm: GLUT is one of the main controlling steps of the glycolytic flux in cells.24 GLUT1 overexpression is associated with tumor progression and chemoresistance in several solid tumor cells including colon.25, 26 To corroborate the finding that targeting the glucose transport pathway could restore tumor response to ADR, RKO cells were transfected with GLUT1 small interference RNA (siRNA) to silence GLUT1 expression.