PDE6B and retinitis pigmentosa 1: The findings in wild-type mice led us to assesses if loss of Tsc1 also impairs autophagy in RP mice (rd1-Tsc1c/cCre+) where cones are subject to conditions of nutrient deprivation.1, 3 Similar to our observations in wild-type mice, rd1-Tsc1c/cCre+ mice showed an accumulation of p62 and ubiquitin aggregates in cones (Figure 2a).