VEGFA and neoplasm: VEGF family and its receptor system is shown as the critical regulator in angiogenesis signaling.34, 35 The production of VEGFA by the tumor affects the angiogenic switch, where new vasculature is formed in and around the tumor, allowing it to grow exponentially.36 LncRNA-TUG1 functions as a ceRNA to regulate VEGFA levels by sponging miRNA-34a.