FOXP3 and depressive symptom measurement: Using a regression model for methylation across all five CpGs (R2 = 0.276; p = 0.024) in female patients, antidepressants (p = 0.004) and age (p = 0.027) (depression p = 0.921; smoking p = 0.273) showed the strongest associations, with lower FOXP3 promoter methylation correlating with antidepressant medication and higher age.