To gain insights into the role of histone modifications in the regulation of gene transcription during tumor resistance to anti-VEGF therapy in LLC tumors, we profiled genome-wide occupancy of key histone modifications (H3K4me3, H3K27me3, H3K36me3, and H3K9ac) for anti-VEGF therapy using high throughput sequencing. This evidence concerns the gene VEGFA and neoplasm.