Moreover, some other pathways were also identified in the present study, such as the MAPK, p53, Wnt, JAK-STAT, ERBB, NF-κB, and ubiquitin mediated proteolysis signaling pathways, which altered during the process of drug-resistance of murine lung cancer isografts in vivo. The gene discussed is NFKB1; the disease is lung carcinoma.