KDR and non-small cell lung carcinoma: Moreover, it was reported that increased VEGFR-2 copy number was associated with chemo-resistance and shorter survival in NSCLC patients who receive adjuvant chemotherapy [41], while another recent study showed that capsaicin, an active component of chili peppers, was able to restrain angiogenesis to achieve more efficient and cogent therapy of resistant NSCLC cells.