Lodillinsky and collaborators (2015) [60] showed that the transition from ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires membrane-type 1 (MT1) matrix metalloproteinase (MMP)/p63 axis activation, reinforcing p63 as an inhibitor of tumor invasiveness. This evidence concerns the gene TP63 and ductal breast carcinoma in situ.