TP53 and vulvar intraepithelial neoplasia: Numerous epidemiological, clinical, pathological and molecular studies indicate the existence of two etiologies of vulvar carcinomas: in the first group, women are older–from 55 to 85 years old–and develop lichen sclerosus associated carcinomas, squamous hyperplasia, differentiated vulvar intraepithelial neoplasia (VIN), and TP53 mutations, not being these tumors directly associated with HPV infection [5–7].