YAP1 and hepatocellular carcinoma: Indeed, YAP is able to inhibit the growth of human malignant cells by activating apoptogenic p73 pathway [13], the PML (Promyelomonocytic leukemia) oncosuppressor protein interacts with YAP1, enhancing its stabilization [14], and YAP increases chemosensitivity of HCC cells by modulating p53 [15].