YAP-TEAD signaling was previously shown to activate the promoters of OCT-3/4 and NANOG stem cell markers [22], and recent results [18] showed overexpression of CD90, a cancer stem cell marker, in HCC cell lines in which YAP1 expression was stimulated as a consequence of TAZ inhibition. This evidence concerns the gene YAP1 and hepatocellular carcinoma.