NOS2 and hepatocellular carcinoma: Previous work in our laboratory, has shown highest over-expression of iNOS/NF-kB (inducible nitric oxide synthase/nuclear factor-kB), RAS/ERK (extracellular signal-regulated kinase), FoxM1 (Forkhead box M1B), Mybl2 (v-Myb avian myeloblastosis viral oncogene homolog-like2), and decrease in methionine metabolism, in the human HCC subtype with poorer prognosis (< 3 years survival, after partial liver resection, HCCP), and low/absent in the human HCC subtype characterized by better outcome (> 3 years survival; HCCB) [1].