These findings were associated with a sharp decrease in phosphorylated Yap1-ser127 and increase in phosphorylated Yap1-tyr357 in HCC of both rat strains, with respect to normal liver, with lowest values of pYap1-ser127 in F344 HCC and highest values of pYap1-tyr357 in BN HCC, respectively (Figure 3D, 3E). Here, YAP1 is linked to hepatocellular carcinoma.