Present results indicate that YAP1 post-translational deregulation favoring its ubiquitination, activation of p73, and apoptosis, is significantly higher in well-differentiated and slow-growing HCC of the genetically resistant BN strain, whereas YAP1 post-translational regulation seems to favor HCC fast growth in susceptible F344 rats. This evidence concerns the gene YAP1 and hepatocellular carcinoma.