ASXL1, SETD2, JAK2, KRAS, PTPN11, NRAS, BRAF and CBL were found in AML and other myeloproliferative neoplasms such as myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) with varying frequency and prognostic impact [12–14]. The gene discussed is ASXL1; the disease is acute myeloid leukemia.