Because p-IGF1R induce PI3K-AKT pathway activation and MMP3 can directly induce epithelial-mesenchymal transition [14], a widely known mechanisms of chemotherapy-resistance, we hypothesize that GIST patients with positive immunophenotype (either p-IGF-1R positive or MMP7 positive) can contribute to IM resistance. The gene discussed is MMP3; the disease is gastrointestinal stromal tumor.