For instance, the expression of c-MYC (red node in Fig. 3, and interaction between miRNA and targeting metabolic genes via c-MYC are in red lines in Fig. 4) is regulated by let-7a in Burkitt Lymphoma [92], miR-145 in non-small cell lung cancer [93], let-7g and miR-744 in hepatocellular carcinoma cells [94], [95], miR-34 in prostate cancer cells [96], miR-135b in osteosarcoma cells [97], miR-155 in gastric carcinoma cells [98], miR-320b in colorectal cancer [99] and miR-451 in head and neck squamous cell carcinoma [100]. Here, MYC is linked to osteosarcoma.