Namely, in a study of snoRNA on non-small cell lung carcinoma that showed increased expression of SNORD33, SNORD66, SNORD73B, SNORD76, SNORD78, and SNORA41, subsets of overexpressed snoRNA, SNORD33, SNORD66, SNORD76 were reliably detectable in the NSCLC patients' plasma at a significantly higher level compared to healthy controls or COPD patients. The gene discussed is SNORD33; the disease is chronic obstructive pulmonary disease.