INS and Insulin resistance: In this study, patients treated with OCA showed increased serum levels of insulin and a higher homeostasis model assessment (HOMA) index, a finding that disagrees with previous studies where short‐term administration of OCA improved insulin sensitivity in diabetic patients.68 It should be noted that the HOMA index is an imperfect method to assess insulin resistance in diabetic patients,70 which ideally should be assessed using a hyperinsulinemic euglycemic clamp.