MAPT and tauopathy: Histology revealed a prominent tauopathy, characterized by numerous Gallyas-positive neurofibrillary tangles (NFT), diffuse granular cytoplasmic phospho-tau (pTau) immunoreacitivity (pretangles), and neuropil threads involving predominantly the hypothalamus, zona incerta, hippocampus, tegmentum of brainstem (mesencephalon, pons and medulla), and cervical spinal cord (Table 3; Fig. 1) in a symmetrical fashion.