However, the anti-IgLON5-related tauopathy can clearly be differentiated from PSP, even from its variants with more restricted tau pathology [4, 18] or other 4R tauopathies such as corticobasal degeneration (CBD) [4], globular glial tauopathies (GGT) or argyrophilic grain disease (AgD) by the morphological patterns of the tau pathology, including the absence of glial pathology (tufted astrocytes or coiled bodies), and sparse supratentorial and basal ganglia involvement [11]. This evidence concerns the gene IGLON5 and red-green color blindness.