Such work has shown that Nf2-, Mst1/2- and Sav1-liver-specific knockout mice and YAP wild-type (WT) or S127A over-expressing mice exhibited varying degrees of hepatomegaly, over-proliferation of biliary/progenitor cells and hepatocellular carcinoma (HCC)9, 19, 20, 21, 22, 23, 24, 25, 26. Here, MST1 is linked to hepatocellular carcinoma.