Significant overlap (71 genes, P < 10−4; permutation analysis) was observed amongst the three sources of cancer drivers and a smaller but still significant overlap of four genes (B4GALT3, CYC1, GMPS and SLC25A10) was observed between the combined list from the three databases and the metabolic signature (P = 0.045, hypergeometric test) (Fig. 2a). The gene discussed is SLC25A10; the disease is cancer.