TP53 and breast cancer: Since we observed a modest increase in SQLE mRNA abundance in the TP53 mutant group in breast cancer (Additional file 1 and Additional file 2: Table S12), we further interrogated this association with TP53 mutation status in the TCGA breast cancer cohort (where all data modalities were available) and found that SQLE’s prognostic ability was decreased when adjusting for TP53 mutation status (P = 0.03 to 0.18) (Additional file 1: Figure S8).