This study aimed to investigate whether and how the plasma concentrations of eight soluble bio-molecules, namely Neopterin, sCD163, suPAR, Pentraxin3, sCD14, Fractalkine/CX3CL1, sTREM-1 and MIG/CXCL9, differ among young patients presenting with distinct clinical manifestations of malaria. This evidence concerns the gene CX3CL1 and malaria.