This is accompanied by downregulation of E3 ubiquitin-protein ligase TRAF2 also known as tumor necrosis factor type 2 receptor-associated protein (TRAF2) [Q12933], tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD), which usually acts as a tumor suppressor [Q15628], and NF-kappa-B essential modulator (NEMO) [SwissProt:Q9Y6K9], which usually form a complex activating receptor interacting protein (RIP1). This evidence concerns the gene TRADD and neoplasm.