As FADD‐D mice have enhanced oxidative phosphorylation and reduced WAT, this may partly contribute to the fact that FADD‐D mice are resistant to diet‐induced obesity, which is related to the oxidative phosphorylation pathway (Dressel et al, 2003; Luquet et al, 2003). The gene discussed is FADD; the disease is obesity due to melanocortin 4 receptor deficiency.