The majority of the increase in macrophages with obesity is due to M1‐like macrophages (triply positive, CD11b+, CD11c+, and F4/80+ cells), which overexpress proinflammatory cytokines relative to the M2‐like macrophages (CD11c−) (Hevener et al, 2007). This evidence concerns the gene ITGAM and obesity due to melanocortin 4 receptor deficiency.