Tet1 depletion inhibits the growth of NIH3T3 cells by blocking cyclin D1 accumulation in G1 phase, inhibiting Rb phosphorylation and consequently delaying entrance to G1/S phase.36 The reduction of TET1 significantly downregulated proliferating cell nuclear antigen, thus inhibiting cell proliferation in human uterine leiomyoma.37 In the present study, TET1 knockdown suppressed cell growth from the second day onward, suggesting that the loss of TET1 inhibited the proliferation of the hDPCs. The gene discussed is RB1; the disease is uterine corpus leiomyoma.