Although great progress has been made in understanding the mechanism underlying oestrogen-deficient osteoporosis within the past several years, it remains unknown how bone loss is caused by ageing, which may be correlated to SIRT6-based mechanisms according to previous research.3 Age-related bone loss is associated with ageing in both genders, and there is a greater decrease in bone formation by osteoblasts and a significant increase in bone resorption by osteoclasts,4 which consequently results in osteoporosis. The gene discussed is SIRT6; the disease is osteoporosis.