KCNN2 and ischemia: Furthermore, SK2 channels act neuroprotective in ischemia-induced neuronal cell death (Allen et al. 2011a), and moreover, activation of SK2 channels seems to block pathological Ca2+ influx from the extracellular space in the context of glutamate excitotoxicity and, therefore, promotes neuroprotection (Dolga and Culmsee 2012).