The reduced pregnancy rate in PCOS patients has been attributed to the oligo-anovulatory condition of the syndrome; this, in part, stems from a disrupted intrafollicular milieu, which includes reductions in cortisone [5], insulin growth like factor (IGF) I and II [6], and progesterone (P4) [7], increases in anti-Mullerian hormone (AMH) [8], testosterone, androstenedione, and proteomic dysregulation [9]. The gene discussed is AMH; the disease is polycystic ovary syndrome.