Furthermore, we found several additional characteristic features of ccRCC, namely, (a) lower levels of PE and CL; (b) an altered Cer/SM ratio; (c) higher levels of ePC and ePE lipids; (d) unchanged levels of COX metabolites on the background of lower levels of their substrate PUFAs; and (e) modification of major PC fatty acid side chains. The gene discussed is CBLN1; the disease is nonpapillary renal cell carcinoma.