GPHN and Alzheimer disease: Gephyrin, a post synaptic GABA-A associated protein which anchors GABAergic and glycinergic receptors to the post-synaptic cytoskeleton [61] showed a significant reduction of approximately 25 % in DLB compared to control (P < 0.001, uncorrected) and in AD a reduction of about 20 % (P < 0.0001, uncorrected).