Assessment of amyloid-β and tau pathology demonstrated that the primary visual cortex in AD showed a high level of amyloid-β pathology in the form of senile plaque and diffuse amyloid-β deposition, which was significantly higher than in controls and also higher than in DLB (P < 0.005 vs control; P < 0.05 vs DLB, see Additional file 6: Figure S1). Here, MAPT is linked to Alzheimer disease.