Luteolin, another dietary flavonoid, has been found to inhibit 26S proteasome (24) and activate the type I IFNs-induced JAK/STAT pathway by enhancing cAMP-hydrolyzing activity of phosphodiesterases and decreasing intracellular cAMP levels for the suppression of PKA-mediated inhibition of protein tyrosine phosphatase SHP2 in cancer cells (12). The gene discussed is PTPN11; the disease is cancer.