Acetyl-K274 tau was localized in the cytoplasm of neurons of FTDP-17 patients (Additional file 1: Figure S1A) and also in the corticobasal bodies of patients with A152T mutation (Additional file 1: Figure S1B), which is linked with increased risk of AD and progressive supranuclear palsy (PSP) [42]. Here, MAPT is linked to Alzheimer disease.