Using bone marrow (BM) as a source of cDCs, we found differences in maturation, proliferation, cytokine secretion and gene expression between AIP-prone MRL/MpJ mice and an AIP-resistant control strain, CAST/EiJ, that are compatible with the hypothesis of a dysregulated DC activation in the context of murine AIP. The gene discussed is CAST; the disease is autoimmune pancreatitis.