However, the use of IFN–blocking agents could block or decrease the effector functions of the CD8+ T and NK cells which are the major anti-tumor effectors populations, for this reason the use of inducible promoters might represent a more attractive strategy for IL-15 immuno-gene-therapy applications [51] to maintain the antitumoral activity and reducing the negative effects of overexpression of this cytokine. This evidence concerns the gene IFNA1 and neoplasm.