BCL11B and acute lymphoblastic leukemia: However, the genetic or epigenetic alteration as well as the tumor microenvironment may be the important factors to influence the outcome and survival [30, 31], for example, low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-ALL patients, our previous study showed overexpression of BCL11b in T-ALL samples including sample from this case [32], is this one of the possible role in this case with unusually long survival, it remains an open question.