CCR4 and colorectal carcinoma: Moreover, the results from orthotopic model showed that CCR4 played a positive role in metastasis of CRC cells (Vector: 1.20 ± 0.79 versus CCR4: 3.40 ± 1.07, sh-NC: 3.37 ± 1.07 versus sh-CCR4: 1.90 ± 0.74, Figure 3F).