KIR3DL1 and neoplasm: To overcome such matched barrier or upregulated expression of inhibitory receptors induced by activation, blocking KIR/MHC-I engagement using anti-KIR antibodies to create KIR/MHC-I miss-match or “allo-NK activity” environment could be one promising approach for enhancing NK cell-mediated killing of tumor cells and efficacy of NK cell adoptive therapy [56, 57].