Indeed, adenoviral E1A, a gene product in the adenoviral early region, exerts tumor suppressive functions, including enhancement of chemotherapy-induced apoptosis via stabilization of tumor suppressors such as p53 and p2110 and inhibition of cell proliferation via suppression of epidermal growth factor receptor (EGFR)11 and HER212. Here, DHTKD1 is linked to neoplasm.