Cystogenesis in human ADPKD and several mouse models of PKD is associated with dysregulation of multiple biochemical pathways, such as cell‐cycle regulation, apoptosis, cyclic AMP, MAPK/ERK, Akt/mTOR, and canonical Wnt/β‐catenin signaling cascades (Takiar and Caplan 2011). The gene discussed is MTOR; the disease is autosomal dominant polycystic kidney disease.