Strategies used for anemia management were RBV dose reduction [32 patients (15.8%)], EPO [15 (7.4%)], combination of EPO and RBV dose reduction [55 (27%)], EPO and PRBC transfusion [2 (0.9%)], RBV dose reduction and PRBC transfusion [3 (1.5%)] and the three strategies combined [29 (14.2%)]. The gene discussed is EPO; the disease is anemia (phenotype).