CASP3 and asphyxia: In thatstudy, caspase-3 positive-neurons and TUNEL staining were increased in the hippocampusof rats submitted to perinatal asphyxia (10-15 min) on postnatal days 1, 3, and 7.Hattori et al. (28) administered blood cells fromumbilical cord intraperitoneally after hypoxic-ischemic brain injury in a neonatal ratmodel and found antiapoptotic and antioxidative effects 24 h later, demonstrated by adecrease in the number of cells positive for active caspase-3.