Examples of these include HGF inhibition, which reportedly reduces colon cancer tumor growth [110], potentially by reducing Wnt activity, and thereby CSC frequencies [31,111]; or similarly, direct targeting of c-Met, the HGF receptor, that reduces CSC numbers in head and neck squamous cell carcinoma (HNSCC) [112]. The gene discussed is MET; the disease is head and neck squamous cell carcinoma.