In BM-MSPCs from MDS patients, altered expression levels of several chemokines as well as of gene sets associated with differentiation, fibrosis, adhesion, extracellular matrix remodeling, and key molecules involved in the crosstalk with HSCs and HSPCs, including up-regulation of Notch ligand Jagged1, were reported [33,279]. Here, JAG1 is linked to myelodysplastic syndrome.