NES and cancer: However, it must be borne in mind that although Nestin is an important marker for a subset of BM-MSPCs that contribute to HSC maintenance, it is by no means specific for these cells; rather, Nestin+ cells are a heterogeneous cell population comprising MSPCs, neural crest-derived SCs (NCSCs) [157,158], ECs [159], endothelial precursor cells [160], myofibroblasts [161], and cancer cells [162].