In 2011, one study compared the hCRH with the desmopressin test using the new criteria and verified the identical and excellent performance of both tests in the differential diagnosis of ACTH-dependent Cushing’s syndrome and states of pseudo-Cushing’s, with a 96.6% sensitivity and 100% specificity for both tests (91), results even better than both first-line methods and nocturnal serum cortisol. This evidence concerns the gene POMC and Cushing syndrome.