Regarding the follow-up of patients with occult EAS with tumors that have not been localized, after proper treatment for hypercortisolism, they should be submitted at least once a year to new anatomical imaging of the cervical and thoracic/abdominal/pelvic regions, with special consideration to the chest, as a ACTH-producing source may appear many years after the onset of symptoms, with bronchial carcinoid being the most common cause (181). The gene discussed is POMC; the disease is adrenal gland hyperfunction.