A recent report demonstrated that myocardial expression of HMGB1 protein and its translocation from nucleus to both cytoplasm and intercellular space were increased in mice with TAC, and exogenous HMGB1 aggravated TAC-induced cardiac hypertrophy [32], but it is unclear whether HMGB1-RAGE axis is involved in cardiac hypertrophy. This evidence concerns the gene AGER and cardiac hypertrophy.