Moreover, genes with a AFNC-selected non-synonymous or splice-site variant have been associated with CVD (BRD2 [79], CNR2 [80–82], KCNN4 [83–86], MME [87, 88], NLRP1 [89], SDHB [90], TACR3 [91, 92], TNNI3K [93–95]) or related conditions, such as diabetes (CLEC16A [96]), obesity (OPRM1 [97, 98]), chronic obstructive pulmonary disease (PDE4A [99–102]), and diabetic peripheral neuropathy (SCN9A [103, 104]). This evidence concerns the gene PDE4A and chronic obstructive pulmonary disease.