PIAS4 and cancer: A number of genes participates in cellular pathways involved in cancer development such as CCKR signaling (PTK2, TRAF6, RPS6KA1, AKT1S1, ITGB1, STAT3, FOXO1, MAPK14, CSK, PRKCH, RAC1, SRC, MAPK10, IL8, PRKCQ, MEF2C, CREM, AKT1), Wnt signaling (SMARCD4), PDGF signaling (PDGFRB, MAPKAPK2, DLC1, PDGFRA, RPS6KA1, PRKCA, RPS6KA2, RASA4, VAV3), Toll receptor signaling (TRAF6, MAP2K3, TICAM1), Jak-STAT signaling (JAK2, JAK3, PIAS4) and inflammation mediated by chemokine and cytokine FPR3, GNG8, RGS4, RGS13, C5AR1, RAC1, CCL22, FBX044, STAT6, ARPC2, VAV1, IL8, CCR7) among others (Fig 4).