DNMT1 and neoplasm: For instance, resveratrol inhibits the activity and expression of DNA methyltransferase 1 (DNMT1) in breast cancer cells, which impairs the epigenetic silencing of the BRCA1 tumor suppressor by modulating acetylation of H3K9, and H4, association of mono-methylated-H3K9, DNMT1, and methyl binding domain protein-2 with the promoter of BRCA-1 gene [27].