HK2 and cancer: In agreement with a recent report here we identified hypomethylated oncogenes (HK2, FGFR4, DNMT3A) and methylated tumor suppressor genes (CDO1, SLIT3, and SOX17), which were previously identified as candidate genes that comprise part of the emerging “cancer methylome” from 22 cancer cell lines derived from several cancer types as lung, breast, colon, liver, skin, prostate, and cervical cancer, among others [20–22].