SLIT3 and breast cancer: Moreover, our aPRIMES approach indicates that resveratrol treatment restores the hypomethylated status of transcription factor SOX-17 (SOX-17), slit guidance ligand 3 (SLIT3), and cysteine dioxygenase type 1 (CDO1), three well known tumor suppressors that are frequently suppressed by hypermethylation in breast cancer [20, 21, 22].