In addition, humans with hypogonadotropic hypogonadism are characterized by a failure to undergo puberty and have been described to possess one of approximately six different forms of mutations in GNRH1 [17], in which one of the mutational “hot spots” tends to be in the region encoding the decapeptide [18]. This evidence concerns the gene GNRH1 and hypogonadotropic hypogonadism.