NFKB1 and cancer: Furthermore, luteolin can sensitize cancer cells to therapeutic-induced cytotoxicity through a variety of mechanisms including suppression of cell cycle pathways like phosphatidylinositol 3′-kinase (PI3K)/Akt, NF-κB, and X-linked inhibitor of apoptosis protein (XIAP) and stimulating apoptosis pathways including those that induce the tumor suppressor p53 [178].