In the cerebrovascular endothelium, monocarboxylic acid transporter 1 (Mct1) controls blood-brain transport of short chain monocarboxylic acids such as L-lactate, acetate, pyruvate, ketone bodies, acetoacetate and β-hydroxybutyrate monocarboxylic and ketoacids to support energy metabolism and play potential role in treating brain diseases (Table 2) [66]. Here, SLC16A1 is linked to brain disorder.